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Empower your epigenetics and nuclear signaling research with our premium-quality Recombinant Human SSB protein. The Lupus La protein, also known as SSB, plays a crucial role in RNA processing, stability, and maturation. It is a prominent target for the production of autoantibodies in patients with autoimmune disorders such as systemic lupus erythematosus (SLE) and Sj?gren's syndrome. Investigating the function and regulation of this protein offers valuable insights into RNA metabolism and autoimmunity. Our Recombinant Human SSB protein has been meticulously produced in E. coli, ensuring a robust and reliable expression system. The full-length protein (1-408 amino acids) is designed to retain the structural and functional properties of the native protein, enabling accurate and meaningful experimental results. The N-terminal 6xHis-SUMO-tag allows for efficient purification while maintaining the bioactivity of the protein. With a purity of greater than 90% as determined by SDS-PAGE, this Recombinant Human SSB protein is an excellent choice for advancing your epigenetics and nuclear signaling research. Choose our high-quality protein to elevate your experiments and uncover new insights into RNA metabolism and the molecular basis of autoimmunity.
Empower your epigenetics and nuclear signaling research with our premium-quality Recombinant Human SSB protein. The Lupus La protein, also known as SSB, plays a crucial role in RNA processing, stability, and maturation. It is a prominent target for the production of autoantibodies in patients with autoimmune disorders such as systemic lupus erythematosus (SLE) and Sj?gren’s syndrome. Investigating the function and regulation of this protein offers valuable insights into RNA metabolism and autoimmunity.
Our Recombinant Human SSB protein has been meticulously produced in E. coli, ensuring a robust and reliable expression system. The full-length protein (1-408 amino acids) is designed to retain the structural and functional properties of the native protein, enabling accurate and meaningful experimental results. The N-terminal 6xHis-SUMO-tag allows for efficient purification while maintaining the bioactivity of the protein. With a purity of greater than 90% as determined by SDS-PAGE, this Recombinant Human SSB protein is an excellent choice for advancing your epigenetics and nuclear signaling research. Choose our high-quality protein to elevate your experiments and uncover new insights into RNA metabolism and the molecular basis of autoimmunity.
| Cat.No | ACP02425 | Target Name | SSB |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 1-408aa | Mol Weight | 62.8kDa |
| Protein Length | Full length | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P05455 |
|---|
Uniprot Id
P05455
Target Species
Human
Target Name
SSB
Target Full Name
Lupus La protein
Target Function
Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation. In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation.
Target Subcellular Location
Nucleus.
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
Autoantigen La; La ; La autoantigen; La autoantigen homolog; La protein; La ribonucleoprotein; La ribonucleoprotein domain family member 3; LA_HUMAN; LARP3; Lupus La antigen; Lupus La protein; Lupus La protein homolog ; MGC118101; MGC93380; mRNA for autoantigen; OTTMUSP00000014043; RP23 273G23.1; Sjoegren syndrome type B antigen; Sjogren syndrome antigen B (autoantigen La); Sjogren syndrome antigen B; SS B; SS-B; SS-B/La protein ; SSB
Target Background
The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein.
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