Recombinant Human Lutropin-choriogonadotropic hormone receptor (LHCGR), Truncated

Uniprot Id

P22888

Target Species

Human

Target Name

LHCGR

Target Full Name

Lutropin-choriogonadotropic hormone receptor

Target Function

Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

Target Involvement

Familial male precocious puberty (FMPP); Luteinizing hormone resistance (LHR)

Target Subcellular Location

Cell membrane; Multi-pass membrane protein.

Target Protein Families

G-protein coupled receptor 1 family, FSH/LSH/TSH subfamily

Target Tissue Specificity

Gonadal and thyroid cells.

Target Research Area

Cardiovascular, Neuroscience

Target Synonyms

Gonadotropin receptor; Gpcr19-rs1; GTHR-II; HHG; LCGR; LGR2; LH-R; LH/CG R; LH/CG-R; LH/CGR; LHCGR; LHR; LHRHR; LSH R; LSH-R; LSHR_HUMAN; Luteinizing hormone receptor; Luteinizing hormone/choriogonadotropin receptor; Lutropin choriogonadotropic hormone receptor ; Lutropin choriogonadotropic receptor ; Lutropin-choriogonadotropic hormone receptor; ULG5

Target Background

This gene encodes the receptor for both luteinizing hormone and choriogonadotropin. This receptor belongs to the G-protein coupled receptor 1 family, and its activity is mediated by G proteins which activate adenylate cyclase. Mutations in this gene result in disorders of male secondary sexual character development, including familial male precocious puberty, also known as testotoxicosis, hypogonadotropic hypogonadism, Leydig cell adenoma with precocious puberty, and male pseudohermaphtoditism with Leydig cell hypoplasia.