Chinese (Simplified)
English
German
Korean
Spanish
Sign up for an account to enjoy easy online shopping and instant order tracking.
Recombinant Human Lymphocyte antigen 6E (LY6E) with an N-terminal 6xHis-SUMO-tag is a full-length of mature protein expressed in E.coli. The sequence used to prepare this recombinant LY6E protein corresponds to residues Leu21-Ser101 of Human LY6E. Its purity is greater than 90% determined by SDS-PAGE. A molecular mass band of approximately 24 kDa was visualized on the gel. And in-stock LY6E proteins are offered now. This recombinant LY6E protein may be used to produce specific anti-LY6E antibodies or in the studies of cell biology. LY6E, also called SCA2 or TSA1, is a member of the LY6/uPAR family of glycosylphosphatidylinositol-anchored proteins. It exerts roles in multiple cellular processes, such as T-cell differentiation, the regulation of the T-cell receptor signaling pathway of activated T cells, and the self-renewal of erythroid progenitors. Stephanie Pfaender etc. recently demonstrated that LY6E is a key antiviral immune effector that controls coronavirus (CoV) infection and pathogenesis through the inhibition of CoV entry into cells by interfering with spike protein-mediated membrane fusion. And LY6E is overexpressed in diverse human malignant cells.
Recombinant Human Lymphocyte antigen 6E (LY6E) with an N-terminal 6xHis-SUMO-tag is a full-length of mature protein expressed in E.coli. The sequence used to prepare this recombinant LY6E protein corresponds to residues Leu21-Ser101 of Human LY6E. Its purity is greater than 90% determined by SDS-PAGE. A molecular mass band of approximately 24 kDa was visualized on the gel. And in-stock LY6E proteins are offered now. This recombinant LY6E protein may be used to produce specific anti-LY6E antibodies or in the studies of cell biology.
LY6E, also called SCA2 or TSA1, is a member of the LY6/uPAR family of glycosylphosphatidylinositol-anchored proteins. It exerts roles in multiple cellular processes, such as T-cell differentiation, the regulation of the T-cell receptor signaling pathway of activated T cells, and the self-renewal of erythroid progenitors. Stephanie Pfaender etc. recently demonstrated that LY6E is a key antiviral immune effector that controls coronavirus (CoV) infection and pathogenesis through the inhibition of CoV entry into cells by interfering with spike protein-mediated membrane fusion. And LY6E is overexpressed in diverse human malignant cells.
| Cat.No | ACP02538 | Target Name | Ly6e |
|---|---|---|---|
| Target Synonyms | LY6E; 9804; RIGE; SCA2; TSA1; Lymphocyte antigen 6E; Ly-6E; Retinoic acid-induced gene E protein; RIG-E; Stem cell antigen 2; SCA-2; Thymic shared antigen 1; TSA-1 | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 21-101aa |
| Mol Weight | 24.5kDa | Protein Length | Full Length of Mature Protein |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q16553 |
|---|
Uniprot Id
Q16553
Target Species
Human
Target Name
LY6E
Target Full Name
Lymphocyte antigen 6E
Target Function
GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. Regulates the T-cell receptor (TCR) signaling by interacting with component CD3Z/CD247 at the plasma membrane, leading to CD3Z/CD247 phosphorylation modulation. Restricts the entry of human coronaviruses, including SARS-CoV, MERS-CoV and SARS-CoV-2, by interfering with spike protein-mediated membrane fusion. Plays also an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). Therefore, participates in the normal fusion of syncytiotrophoblast layer I (SynT-I) and in the proper morphogenesis of both fetal and maternal vasculatures within the placenta. May also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity.; (Microbial infection) Promotes entry, likely through an enhanced virus-cell fusion process, of various viruses including HIV-1, West Nile virus, dengue virus and Zika virus. In contrast, the paramyxovirus PIV5, which enters at the plasma membrane, does not require LY6E. Mechanistically, adopts a microtubule-like organization upon viral infection and enhances viral uncoating after endosomal escape.
Target Subcellular Location
Cell membrane; Lipid-anchor, GPI-anchor.
Target Tissue Specificity
Widely expressed, predominantly in liver, kidney, ovary, spleen and peripheral blood Leukocytes.
Target Research Area
Cell Biology
Target Synonyms
LY6E; 9804; RIGE; SCA2; TSA1; Lymphocyte antigen 6E; Ly-6E; Retinoic acid-induced gene E protein; RIG-E; Stem cell antigen 2; SCA-2; Thymic shared antigen 1; TSA-1
Target Background
This gene belongs to the human Ly6 gene family and encodes a glycosylphosphatidyl-inositol (GPI)-anchored cell surface protein. The protein plays an important role in T cell physiology, oncogenesis and immunological regulation. The protein is also involved in modulation of viral infection by coronaviruses, SARS-CoV, MERS-CoV and SARS-CoV-2.
Free shipping on orders $999+
Advenit post multos Scudilo Scutariorum tribunus velament
We accept credit cards, PayPal, and bank wires
Responsive and knowledgable customer service via email, text or phone
Notification
