Recombinant Human Lymphoid-restricted membrane protein (LRMP), Truncated

Uniprot Id

Q12912

Target Species

Human

Target Name

IRAG2

Target Full Name

Inositol 1,4,5-triphosphate receptor associated 2

Target Function

Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion. Plays a role in maintaining nuclear shape, maybe as a component of the LINC complex and through interaction with microtubules.

Target Subcellular Location

[Processed inositol 1,4,5-triphosphate receptor associated 2]: Cytoplasm.; Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Nucleus envelope. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Chromosome.

Target Protein Families

LRMP family

Target Tissue Specificity

Expressed at high levels in pre B-cells, mature B-cells and pre T-cells. Expressed at low levels in mature T-cells and plasma B-cells. Expressed in germinal center B-cells, splenic marginal zone cells and B-cell lymphomas. Expressed in neuronal cells in t

Target Synonyms

Lrmp; LRMP_HUMAN; Lymphoid restricted membrane protein; Processed lymphoid-restricted membrane protein; Protein Jaw1

Target Background

The protein encode dby this gene is expressed in a developmentally regulated manner in lymphoid cell lines and tissues. The protein is localized to the cytoplasmic face of the endoplasmic reticulum.