Recombinant Human Lysine-specific demethylase 5B (KDM5B), Truncated

Cat.No	ACP10821	Target Name	KDM5B
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Protein Length	Partial	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP10821

Target Name

KDM5B

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Protein Length

Partial

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q9UGL1

Background Information

Uniprot Id

Q9UGL1
Target Species

Human
Target Name

KDM5B
Target Full Name

Lysine-specific demethylase 5B
Target Function

Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2.
Target Subcellular Location

Nucleus.
Target Protein Families

JARID1 histone demethylase family
Target Tissue Specificity

Ubiquitously expressed, with highest levels in testis. Down-regulated in melanoma and glioblastoma. Up-regulated in breast cancer (at protein level).
Target Synonyms

Cancer/testis antigen 31; CT31; Histone demethylase JARID1B; JARID1B; Jumonji AT rich interactive domain 1B; Jumonji/ARID domain-containing protein 1B; Kdm5b; KDM5B_HUMAN; Lysine (K) specific demethylase 5B; Lysine demethylase 5B; Lysine specific demethylase 5B; Lysine-specific demethylase 5B; PLU-1; PLU1; PPP1R98; Protein phosphatase 1 regulatory subunit 98; PUT1; putative DNA/chromatin binding motif; RBBP2H1A; RBP2 like; RBP2-H1; Retinoblastoma-binding protein 2 homolog 1; Retinoblastoma-binding protein 2 homolog 1A
Target Background

This gene encodes a lysine-specific histone demethylase that belongs to the jumonji/ARID domain-containing family of histone demethylases. The encoded protein is capable of demethylating tri-, di- and monomethylated lysine 4 of histone H3. This protein plays a role in the transcriptional repression or certain tumor suppressor genes and is upregulated in certain cancer cells. This protein may also play a role in genome stability and DNA repair. Alternate splicing results in multiple transcript variants.

Recombinant Human Lysine-specific demethylase 5B (KDM5B), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human Lysine-specific demethylase 5B (KDM5B), Truncated Now

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