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| Cat.No | ACP16315 | Target Name | KDM7A |
|---|---|---|---|
| Target Synonyms | JHDM1D; jmjc containing protein; JmjC domain-containing histone demethylation protein 1D; jumonji containing protein; KDM7_HUMAN; kiaa1718; Lysine-specific demethylase 7 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q6ZMT4 |
|---|
Uniprot Id
Q6ZMT4
Target Species
Human
Target Name
KDM7A
Target Full Name
Lysine-specific demethylase 7A
Target Function
Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9', 'Lys-27' and 'Lys-36' (H3K9me2, H3K27me2, H3K36me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate
Target Subcellular Location
Nucleus.
Target Protein Families
JHDM1 histone demethylase family, JHDM1D subfamily
Target Synonyms
JHDM1D; jmjc containing protein; JmjC domain-containing histone demethylation protein 1D; jumonji containing protein; KDM7_HUMAN; kiaa1718; Lysine-specific demethylase 7
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