Recombinant Human Lysosomal thioesterase PPT2 (PPT2)

Uniprot Id

Q9UMR5

Target Species

Human

Target Name

PPT2

Target Full Name

Lysosomal thioesterase PPT2

Target Function

Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S-thioesterase activity for the acyl groups palmitic and myristic acid followed by other short- and long-chain acyl substrates. However, because of structural constraints, is unable to remove palmitate from peptides or proteins.

Target Subcellular Location

Lysosome.

Target Protein Families

Palmitoyl-protein thioesterase family

Target Tissue Specificity

Broadly expressed, with highest levels in skeletal muscle.

Target Synonyms

PPT2Lysosomal thioesterase PPT2; PPT-2; EC 3.1.2.-; S-thioesterase G14

Target Background

This gene encodes a member of the palmitoyl-protein thioesterase family. The encoded glycosylated lysosomal protein has palmitoyl-CoA hydrolase activity in vitro, but does not hydrolyze palmitate from cysteine residues in proteins. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream EGFL8 (EGF-like-domain, multiple 8) gene.