Recombinant Human Macrophage-capping protein (CAPG)

Uniprot Id

P40121

Target Species

Human

Target Name

CAPG

Target Full Name

Macrophage-capping protein

Target Function

Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA.

Target Subcellular Location

Nucleus. Cytoplasm. Melanosome. Cell projection, lamellipodium. Cell projection, ruffle.

Target Protein Families

Villin/gelsolin family

Target Tissue Specificity

Macrophages and macrophage-like cells.

Target Research Area

Immunology

Target Synonyms

Actin capping protein GCAP39; Actin regulatory protein CAP G; Actin regulatory protein CAP-G; AFCP; Capg; CAPG_HUMAN; Capping actin protein gelsolin like; Capping protein (actin filament) gelsolin like; Capping protein gelsolin like; Epididymis secretory protein Li 66; gCap39; Gelsolin like capping protein; HEL S 66; Macrophage capping protein; Macrophage-capping protein; mbh1; MCP; Myc basic motif homolog 1

Target Background

This gene encodes a member of the gelsolin/villin family of actin-regulatory proteins. The encoded protein reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments. By capping the barbed ends of actin filaments, the encoded protein contributes to the control of actin-based motility in non-muscle cells. Alternatively spliced transcript variants have been observed for this gene.