Recombinant Human Macrophage-expressed gene 1 protein (MPEG1), Truncated

Uniprot Id

Q2M385

Target Species

Human

Target Name

MPEG1

Target Full Name

Macrophage-expressed gene 1 protein

Target Function

Plays a key role in the innate immune response following bacterial infection by inserting into the bacterial surface to form pores. By breaching the surface of phagocytosed bacteria, allows antimicrobial effectors to enter the bacterial periplasmic space and degrade bacterial proteins such as superoxide dismutase sodC which contributes to bacterial virulence. Shows antibacterial activity against a wide spectrum of Gram-positive, Gram-negative and acid-fast bacteria. Reduces the viability of the intracytosolic pathogen L.monocytogenes by inhibiting acidification of the phagocytic vacuole of host cells which restricts bacterial translocation from the vacuole to the cytosol. Required for the antibacterial activity of reactive oxygen species and nitric oxide.

Target Subcellular Location

[Isoform 1]: Cytoplasmic vesicle membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.

Target Tissue Specificity

Expressed constitutively in a variety of cell types including macrophages, natural killer cells, neutrophils, keratinocytes and monocytes. In skin, expressed in both hematopoietic and non-hematopoietic cells with expression detected in a variety of cell t

Target Synonyms

macrophage expressed 1; Macrophage expressed gene 1; Macrophage gene 1 protein; Macrophage specific gene 1; Macrophage-expressed gene 1 protein; Mpeg1; MPEG1_HUMAN; Mpg-1; Mpg1; MPS1; MSG