Recombinant Human Macrophage receptor MARCO (MARCO), Truncated

Uniprot Id

Q9UEW3

Target Species

Human

Target Name

MARCO

Target Full Name

Macrophage receptor MARCO

Target Function

Pattern recognition receptor (PRR) which binds Gram-positive and Gram-negative bacteria. Also plays a role in binding of unopsonized particles by alveolar macrophages. Binds to the secretoglobin SCGB3A2.

Target Subcellular Location

Cell membrane; Single-pass type II membrane protein.

Target Tissue Specificity

Expressed in alveolar macrophages (at protein level). Detected in macrophages from various tissues including thymus, kidney, Kupffer cells of liver, and spleen.

Target Synonyms

AI323439; Ly112; Macrophage receptor MARCO; Macrophage receptor with collagenous structure; Marco; MARCO_HUMAN; SCARA2; Scavenger receptor class A member 2

Target Background

The protein encoded by this gene is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains.