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Recombinant Human Male-specific lethal 2 homolog (MSL2)

ACP11239

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Specifications

Cat.No	ACP11239	Target Name	MSL2
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Expression Range	1-577	Protein Length	Full length protein
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q9HCI7

Background Information

Uniprot Id

Q9HCI7
Target Species

Human
Target Name

MSL2
Target Full Name

E3 ubiquitin-protein ligase MSL2
Target Function

Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1.
Target Protein Families

MSL2 family
Target Synonyms

Male specific lethal 2 homolog (Drosophila); Male specific lethal 2 homolog 1; Male specific lethal 2 homolog; Male specific lethal 2 like 1; Male-specific lethal 2 homolog; Male-specific lethal 2-like 1; Male-specific lethal-2 homolog 1; MSL-2; MSL2; MSL2-like 1; MSL2_HUMAN; MSL2L1; Ring finger protein 184
Target Background

Predicted to enable ubiquitin protein ligase activity. Involved in histone H4-K16 acetylation. Part of MSL complex.

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Recombinant Human Male-specific lethal 2 homolog (MSL2)

Specifications

Immunogen Information

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