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Amino acids 1-93 constitute the expression domain of recombinant Human SCGB2A2. The theoretical molecular weight of the SCGB2A2 protein is 37.5 kDa. Expression of this SCGB2A2 protein is conducted in e.coli. Fusion of the N-terminal GST tag into the SCGB2A2 encoding gene fragment was conducted, allowing for easier detection and purification of the SCGB2A2 protein in subsequent stages.Human mammaglobin-A (SCGB2A2) is a protein primarily expressed in mammary glands, particularly in breast tissue. It is implicated in mammary gland development and lactation. In cancer research, Mammaglobin-A is recognized as a sensitive marker for detecting breast cancer metastases. It serves as a prognostic tool, aiding in cancer detection and patient stratification. Furthermore, Mammaglobin-A may have potential applications in targeted therapies for breast cancer. Investigating Mammaglobin-A provides insights into breast biology and therapeutic strategies, offering avenues for advancing breast cancer research and clinical management.
Amino acids 1-93 constitute the expression domain of recombinant Human SCGB2A2. The theoretical molecular weight of the SCGB2A2 protein is 37.5 kDa. Expression of this SCGB2A2 protein is conducted in e.coli. Fusion of the N-terminal GST tag into the SCGB2A2 encoding gene fragment was conducted, allowing for easier detection and purification of the SCGB2A2 protein in subsequent stages.Human mammaglobin-A (SCGB2A2) is a protein primarily expressed in mammary glands, particularly in breast tissue. It is implicated in mammary gland development and lactation. In cancer research, Mammaglobin-A is recognized as a sensitive marker for detecting breast cancer metastases. It serves as a prognostic tool, aiding in cancer detection and patient stratification. Furthermore, Mammaglobin-A may have potential applications in targeted therapies for breast cancer. Investigating Mammaglobin-A provides insights into breast biology and therapeutic strategies, offering avenues for advancing breast cancer research and clinical management.
| Cat.No | ACP03329 | Target Name | SCGB2A2 |
|---|---|---|---|
| Target Synonyms | Mammaglobin 1; Mammaglobin-1; Mammaglobin-A; MGB1; Scgb2a2; Secretoglobin family 2A member 2; SG2A2; SG2A2_HUMAN; UGB2 | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 1-93aa |
| Mol Weight | 37.5kDa | Protein Length | Full length |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q13296 |
|---|
Uniprot Id
Q13296
Target Species
Human
Target Name
SCGB2A2
Target Full Name
Mammaglobin-A
Target Subcellular Location
Secreted.
Target Protein Families
Secretoglobin family, Lipophilin subfamily
Target Tissue Specificity
Mammary gland specific. Over-expressed in breast cancer.
Target Research Area
Tags & Cell Markers
Target Synonyms
Mammaglobin 1; Mammaglobin-1; Mammaglobin-A; MGB1; Scgb2a2; Secretoglobin family 2A member 2; SG2A2; SG2A2_HUMAN; UGB2
Target Background
Predicted to be involved in androgen receptor signaling pathway. Predicted to be located in extracellular region. Predicted to be active in extracellular space.
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