Recombinant Human MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)

Uniprot Id

Q9BUB5

Target Species

Human

Target Name

MKNK1

Target Full Name

MAP kinase-interacting serine/threonine-protein kinase 1

Target Function

May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.

Target Subcellular Location

[Isoform 2]: Cytoplasm.; [Isoform 3]: Cytoplasm. Nucleus.

Target Protein Families

Protein kinase superfamily, CAMK Ser/Thr protein kinase family

Target Tissue Specificity

Ubiquitous.

Target Research Area

Neuroscience

Target Synonyms

MAP kinase interacting kinase 1; MAP kinase interacting serine/threonine kinase 1; MAP kinase signal integrating kinase 1; MAP kinase signal-integrating kinase 1; MAP kinase-interacting serine/threonine-protein kinase 1; MAPK signal integrating kinase 1; MITOGEN-ACTIVATED PROTEIN KINASE-INTERACTING SERINE/THREONINE KINASE 1; mknk1; MKNK1_HUMAN; MNK 1; Mnk1

Target Background

This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene.