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Amino acids 20-96 form the expressed segment for recombinant Human MGP. The expected molecular weight for the MGP protein is calculated to be 13.5 kDa. This MGP recombinant protein is manufactured in e.coli. The MGP gene fragment has been modified by fusing the N-terminal 6xHis tag, providing convenience in detecting and purifying the recombinant MGP protein during the following stages. Human matrix gla protein (MGP) is a vital extracellular matrix protein that plays a key role in preventing vascular calcification. Primarily synthesized by vascular smooth muscle cells and chondrocytes, MGP is known for its ability to inhibit the deposition of calcium in soft tissues, including blood vessels and cartilage. As an antagonist of vascular calcification, MGP helps maintain vascular elasticity and integrity. Dysregulation of MGP has been linked to arterial stiffness and cardiovascular diseases. Research on MGP encompasses cardiovascular health, bone metabolism, and tissue mineralization, emphasizing its significance in understanding and potentially treating conditions related to ectopic calcification and maintaining tissue homeostasis. ?
Amino acids 20-96 form the expressed segment for recombinant Human MGP. The expected molecular weight for the MGP protein is calculated to be 13.5 kDa. This MGP recombinant protein is manufactured in e.coli. The MGP gene fragment has been modified by fusing the N-terminal 6xHis tag, providing convenience in detecting and purifying the recombinant MGP protein during the following stages.
Human matrix gla protein (MGP) is a vital extracellular matrix protein that plays a key role in preventing vascular calcification. Primarily synthesized by vascular smooth muscle cells and chondrocytes, MGP is known for its ability to inhibit the deposition of calcium in soft tissues, including blood vessels and cartilage. As an antagonist of vascular calcification, MGP helps maintain vascular elasticity and integrity. Dysregulation of MGP has been linked to arterial stiffness and cardiovascular diseases. Research on MGP encompasses cardiovascular health, bone metabolism, and tissue mineralization, emphasizing its significance in understanding and potentially treating conditions related to ectopic calcification and maintaining tissue homeostasis.
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| Cat.No | ACP02598 | Target Name | MGP |
|---|---|---|---|
| Target Synonyms | Cell growth inhibiting gene 36 protein; Cell growth-inhibiting gene 36 protein; GAMMA-CARBOXYGLUTAMIC ACID PROTEIN, MATRIX; GIG36; Matrix Gla protein; MGLAP; MGP; MGP_HUMAN; NTI | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 20-96aa |
| Mol Weight | 13.5kDa | Protein Length | Full Length of Mature Protein |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P08493 |
|---|
Uniprot Id
P08493
Target Species
Human
Target Name
MGP
Target Full Name
Matrix Gla protein
Target Function
Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.
Target Involvement
Keutel syndrome (KTLS)
Target Subcellular Location
Secreted.
Target Protein Families
Osteocalcin/matrix Gla protein family
Target Research Area
Developmental Biology, Signal Transduction
Target Synonyms
Cell growth inhibiting gene 36 protein; Cell growth-inhibiting gene 36 protein; GAMMA-CARBOXYGLUTAMIC ACID PROTEIN, MATRIX; GIG36; Matrix Gla protein; MGLAP; MGP; MGP_HUMAN; NTI
Target Background
This gene encodes a member of the osteocalcin/matrix Gla family of proteins. The encoded vitamin K-dependent protein is secreted by chondrocytes and vascular smooth muscle cells, and functions as a physiological inhibitor of ectopic tissue calcification. Carboxylation status of the encoded protein is associated with calcification of the vasculature in human patients with cardiovascular disease and calcification of the synovial membranes in osteoarthritis patients. Mutations in this gene cause Keutel syndrome in human patients, which is characterized by abnormal cartilage calcification, peripheral pulmonary stenosis and facial hypoplasia.
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