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| Cat.No | ACP07561 | Target Name | MRAP2 |
|---|---|---|---|
| Target Synonyms | MRAP2; C6orf117; Melanocortin-2 receptor accessory protein 2; MC2R accessory protein 2 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q96G30 |
|---|
Uniprot Id
Q96G30
Target Species
Human
Target Name
MRAP2
Target Full Name
Melanocortin-2 receptor accessory protein 2
Target Function
Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP. May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidence is required in vivo.
Target Involvement
Obesity (OBESITY)
Target Subcellular Location
Cell membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
Target Protein Families
MRAP family
Target Tissue Specificity
Expressed in the adrenal gland and brain. Not expressed in other tissues.
Target Synonyms
MRAP2; C6orf117; Melanocortin-2 receptor accessory protein 2; MC2R accessory protein 2
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