Recombinant Human Melanoma-associated antigen 11 (MAGEA11)

Uniprot Id

P43364

Target Species

Human

Target Name

MAGEA11

Target Full Name

Melanoma-associated antigen 11

Target Function

Acts as androgen receptor coregulator that increases androgen receptor activity by modulating the receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects of tumor progression.

Target Subcellular Location

Nucleus. Cytoplasm.

Target Tissue Specificity

Expressed in tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma. Expressed in testis, ovary, prostate, cancerous prostate, breast and adrenal tissue.

Target Synonyms

MAGEA11; MAGE11Melanoma-associated antigen 11; Cancer/testis antigen 1.11; CT1.11; MAGE-11 antigen

Target Background

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Two transcript variants encoding different isoforms have been found for this gene.