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| Cat.No | ACP17032 | Target Name | MAGI3 |
|---|---|---|---|
| Target Synonyms | dJ730K3.2; MAGI-3; magi3; MAGI3_HUMAN; Membrane Associated Guanylate kinase Related 3; Membrane associated guanylate kinase, WW and PDZ domain containing 3; Membrane associated guanylate kinase, WW and PDZ domain containing protein 3; Membrane-associated guanylate kinase; Membrane-associated guanylate kinase inverted 3; RP4-730K3.1; SLIPR; WW and PDZ domain-containing protein 3 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q5TCQ9 |
|---|
Uniprot Id
Q5TCQ9
Target Species
Human
Target Name
MAGI3
Target Full Name
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3
Target Function
Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2.
Target Subcellular Location
Cell membrane; Peripheral membrane protein. Cell junction, tight junction. Nucleus.
Target Protein Families
MAGUK family
Target Tissue Specificity
Widely expressed.
Target Synonyms
dJ730K3.2; MAGI-3; magi3; MAGI3_HUMAN; Membrane Associated Guanylate kinase Related 3; Membrane associated guanylate kinase, WW and PDZ domain containing 3; Membrane associated guanylate kinase, WW and PDZ domain containing protein 3; Membrane-associated guanylate kinase; Membrane-associated guanylate kinase inverted 3; RP4-730K3.1; SLIPR; WW and PDZ domain-containing protein 3
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