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Recombinant Human Membrane-associated progesterone receptor component 1 (PGRMC1), Truncated

ACP06410

Number
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High Purity LevelsPrecision and ReliabilityCustomization Options

Specifications


Cat.No ACP06410 Target NamePGRMC1
Target SynonymsPGRMC1; HPR6.6; PGRMC; Membrane-associated progesterone receptor component 1; mPR; Dap1; IZAFormLyophilized powder
Expression SystemCustom Production. Please inquire and provide the desire expression system.Protein LengthPartial
Purity>85% (SDS-PAGE)Storage Buffer5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information


Target SpeciesHumanUniprot IDO00264
Background Information
  • Uniprot Id

    O00264

  • Target Species

    Human

  • Target Name

    PGRMC1

  • Target Full Name

    Membrane-associated progesterone receptor component 1

  • Target Function

    Component of a progesterone-binding protein complex. Binds progesterone. Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan. Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins.

  • Target Subcellular Location

    Microsome membrane; Single-pass membrane protein. Smooth endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion outer membrane; Single-pass membrane protein; Extracellular side.

  • Target Protein Families

    Cytochrome b5 family, MAPR subfamily

  • Target Tissue Specificity

    Widely expressed, with highest expression in liver and kidney. Expressed by endometrial glands and stroma (at protein level).

  • Target Synonyms

    PGRMC1; HPR6.6; PGRMC; Membrane-associated progesterone receptor component 1; mPR; Dap1; IZA

  • Target Background

    This gene encodes a putative membrane-associated progesterone steroid receptor. The protein is expressed predominantly in the liver and kidney.

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