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Recombinant Human Membrane-associated progesterone receptor component 2 (PGRMC2), Truncated

ACP06752

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Specifications

Cat.No	ACP06752	Target Name	PGRMC2
Target Synonyms	PGRMC2; DG6; PMBP; Membrane-associated progesterone receptor component 2; Progesterone membrane-binding protein; Steroid receptor protein DG6	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Protein Length	Partial
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	O15173

Background Information

Uniprot Id

O15173
Target Species

Human
Target Name

PGRMC2
Target Full Name

Membrane-associated progesterone receptor component 2
Target Function

Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan. May serve as a universal non-classical progesterone receptor in the uterus (Probable). Intracellular heme chaperone required for delivery of labile, or signaling heme, to the nucleus. Plays a role in adipocyte function and systemic glucose homeostasis. In brown fat, which has a high demand for heme, delivery of labile heme in the nucleus regulates the activity of heme-responsive transcriptional repressors such as NR1D1 and BACH1.
Target Subcellular Location

Membrane; Single-pass membrane protein. Nucleus envelope. Endoplasmic reticulum.
Target Protein Families

Cytochrome b5 family, MAPR subfamily
Target Tissue Specificity

Expressed by endometrial glands and stroma (at protein level).
Target Research Area

Signal Transduction
Target Synonyms

PGRMC2; DG6; PMBP; Membrane-associated progesterone receptor component 2; Progesterone membrane-binding protein; Steroid receptor protein DG6
Target Background

Enables heme binding activity. Involved in adipose tissue development. Located in endoplasmic reticulum and nuclear envelope.

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Recombinant Human Membrane-associated progesterone receptor component 2 (PGRMC2), Truncated

Specifications

Immunogen Information

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