Recombinant Human Membrane magnesium transporter 1 (MMGT1), Truncated

Uniprot Id

Q8N4V1

Target Species

Human

Target Name

MMGT1

Target Full Name

ER membrane protein complex subunit 5

Target Function

Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes. May be involved in Mg(2+) transport.

Target Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein.

Target Protein Families

Membrane magnesium transporter (TC 1.A.67) family

Target Synonyms

9630048L06Rik; BC032271; EMC5; Membrane magnesium transporter 1; Mmgt1; MMGT1_HUMAN; RGD1566339; RP11-274K13.3; TMEM32; Transmembrane protein 32