Recombinant Human Mesoderm posterior protein 2 (MESP2)

Uniprot Id

Q0VG99

Target Species

Human

Target Name

MESP2

Target Full Name

Mesoderm posterior protein 2

Target Function

Transcription factor with important role in somitogenesis. Defines the rostrocaudal patterning of the somite by participating in distinct Notch pathways. Regulates also the FGF signaling pathway. Specifies the rostral half of the somites. Generates rostro-caudal polarity of somites by down-regulating in the presumptive rostral domain DLL1, a Notch ligand. Participates in the segment border formation by activating in the anterior presomitic mesoderm LFNG, a negative regulator of DLL1-Notch signaling. Acts as a strong suppressor of Notch activity. Together with MESP1 is involved in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm.

Target Involvement

Spondylocostal dysostosis 2, autosomal recessive (SCDO2)

Target Subcellular Location

Nucleus.

Target Synonyms

Basic helix loop helix protein MESP 2; Basic helix loop helix protein MESP2; BHLH protein MesP2; bHLHc6; Class C basic helix-loop-helix protein 6; Hypothetical class II basic helix loop helix protein MESP 2; Hypothetical class II basic helix loop helix protein MESP2; Mesoderm posterior 2; mesoderm posterior 2 homolog (mouse); Mesoderm posterior 2 homolog; Mesoderm posterior protein 2; Mesp 2; MESP2; MESP2_HUMAN; SCDO 2; SCDO2