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Experience the excellence of our Recombinant Human TIMP3 protein, carefully crafted to aid your neuroscience research endeavors. Derived from E. coli expression systems, this partial protein (30-208aa) features an N-terminal 6xHis-tag, ensuring efficient purification and identification. With a purity greater than 90% as assessed by SDS-PAGE, our TIMP3 protein is guaranteed to deliver reliable and reproducible results. Investigate the fascinating world of metalloproteinase inhibitors and their roles in neural processes with our high-quality recombinant protein. Available in both liquid and lyophilized powder forms, our Recombinant Human TIMP3 protein is an indispensable asset for your neuroscience research toolkit.
Experience the excellence of our Recombinant Human TIMP3 protein, carefully crafted to aid your neuroscience research endeavors. Derived from E. coli expression systems, this partial protein (30-208aa) features an N-terminal 6xHis-tag, ensuring efficient purification and identification. With a purity greater than 90% as assessed by SDS-PAGE, our TIMP3 protein is guaranteed to deliver reliable and reproducible results.
Investigate the fascinating world of metalloproteinase inhibitors and their roles in neural processes with our high-quality recombinant protein. Available in both liquid and lyophilized powder forms, our Recombinant Human TIMP3 protein is an indispensable asset for your neuroscience research toolkit.
| Cat.No | ACP02282 | Target Name | TIMP3 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 30-208aa | Mol Weight | 24.8kDa |
| Protein Length | Partial | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P35625 |
|---|
Uniprot Id
P35625
Target Species
Human
Target Name
TIMP3
Target Full Name
Metalloproteinase inhibitor 3
Target Function
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.
Target Involvement
Sorsby fundus dystrophy (SFD)
Target Subcellular Location
Secreted, extracellular space, extracellular matrix.
Target Protein Families
Protease inhibitor I35 (TIMP) family
Target Research Area
Neuroscience
Target Synonyms
HSMRK222; K222; K222TA2; Metalloproteinase inhibitor 3; MIG 5 protein; MIG5 protein ; Protein MIG 5; Protein MIG-5; SFD; Sorsby fundus dystrophy pseudoinflammatory; TIMP 3; TIMP metallopeptidase inhibitor 3; TIMP-3; TIMP3; TIMP3_HUMAN; Tissue Inhibitor of Metalloproteinase 3; Tissue inhibitor of metalloproteinases 3; Tissue inhibitor of metalloproteinases3
Target Background
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy.
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