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| Cat.No | ACP02911 | Target Name | TIMP4 |
|---|---|---|---|
| Target Synonyms | Metalloproteinase inhibitor 4; TIMP 4; TIMP metallopeptidase inhibitor 4; TIMP-4; Timp4; TIMP4_HUMAN; Tissue inhibitor of metalloproteinase 4; Tissue inhibitor of metalloproteinases 4 | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 31-224aa |
| Mol Weight | 26.3kDa | Protein Length | Partial |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q99727 |
|---|
Uniprot Id
Q99727
Target Species
Human
Target Name
TIMP4
Target Full Name
Metalloproteinase inhibitor 4
Target Function
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9.
Target Subcellular Location
Secreted.
Target Protein Families
Protease inhibitor I35 (TIMP) family
Target Tissue Specificity
Abundant in heart and present at low levels in many other tissues.
Target Research Area
Cancer, Cardiovascular
Target Synonyms
Metalloproteinase inhibitor 4; TIMP 4; TIMP metallopeptidase inhibitor 4; TIMP-4; Timp4; TIMP4_HUMAN; Tissue inhibitor of metalloproteinase 4; Tissue inhibitor of metalloproteinases 4
Target Background
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted, netrin domain-containing protein encoded by this gene is involved in regulation of platelet aggregation and recruitment and may play role in hormonal regulation and endometrial tissue remodeling.
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