Recombinant Human Meteorin-like protein (METRNL)

Uniprot Id

Q641Q3

Target Species

Human

Target Name

METRNL

Target Full Name

Meteorin-like protein

Target Function

Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures.

Target Subcellular Location

Secreted.

Target Protein Families

Meteorin family

Target Tissue Specificity

Highly expressed in the skeletal muscle, in subcutaneous adipose tissue, epididymal white adipose tissue depots and heart. Also expressed in brown adipose tissues and kidney.

Target Research Area

Cell Biology

Target Synonyms

Meteorin like glial cell differentiation regulator; Meteorin; glial cell differentiation regulator like; Meteorin-like protein; METRL_HUMAN; Metrnl

Target Background

Predicted to enable hormone activity. Predicted to be involved in several processes, including brown fat cell differentiation; energy homeostasis; and positive regulation of brown fat cell differentiation. Located in extracellular exosome.