Recombinant Human Methyltransferase-like protein 5 (METTL5)

Uniprot Id

Q9NRN9

Target Species

Human

Target Name

METTL5

Target Full Name

rRNA N(6)-adenosine-methyltransferase METTL5

Target Function

Catalytic subunit of a heterodimer with TRMT112, which specifically methylates the 6th position of adenine in position 1832 of 18S rRNA. N6-methylation of adenine(1832) in 18S rRNA resides in the decoding center of 18S rRNA and is required for translation and embryonic stem cells (ESCs) pluripotency and differentiation.

Target Subcellular Location

Nucleus. Cell junction, synapse, presynapse. Cell junction, synapse, postsynapse.

Target Protein Families

Methyltransferase superfamily, PrmA family

Target Tissue Specificity

Expressed from very early development (8 post-conceptual weeks) and expression persists through adulthood in multiple substructures of the brain, including the cerebellar cortex, hippocampus, and striatum.

Target Synonyms

2810410A08Rik; DC3; FLJ10459; HSPC133; mCG_12967; Methyltransferase like protein 5; Methyltransferase-like protein 5; METL5_HUMAN; METTL 5; METTL5; MGC187943; OTTHUMP00000205107; OTTHUMP00000205108; OTTHUMP00000205109; OTTMUSP00000040951; RGD1566062

Target Background

Enables S-adenosyl-L-methionine binding activity and rRNA (adenine-N6-)-methyltransferase activity. Involved in positive regulation of translation and rRNA methylation. Located in nucleus; postsynapse; and presynapse. Implicated in autosomal recessive intellectual developmental disorder-72.