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| Cat.No | ACP24706 | Target Name | MICB |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Mol Weight | 32.8 kDa | Purity | >85% as determined by SDS-PAGE and HPLC. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q29980 |
|---|
Uniprot Id
Q29980
Target Species
Human
Target Name
MICB
Target Full Name
MHC class I polypeptide-related sequence B
Target Function
Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
Target Involvement
Rheumatoid arthritis (RA)
Target Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Target Protein Families
MHC class I family, MIC subfamily
Target Tissue Specificity
Widely expressed with the exception of the central nervous system where it is absent. Expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In hepatocellular carcinomas, expressed in tumor cells but not in s
Target Synonyms
MHC class I chain related protein B; MHC class I chain related protein B2; MHC class I like molecule PERB11.2 IMX; MHC class I mic B antigen; MHC class I polypeptide related sequence B; MHC class I polypeptide-related sequence B; MIC B; MIC-B; MICB; MICB_HUMAN; PERB11.2; Stress inducible class I homolog
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