Recombinant Human Microsomal glutathione S-transferase 1 (MGST1), Truncated

Uniprot Id

P10620

Target Species

Human

Target Name

MGST1

Target Full Name

Microsomal glutathione S-transferase 1

Target Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity.

Target Subcellular Location

Microsome. Mitochondrion outer membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Target Protein Families

MAPEG family

Target Tissue Specificity

Highly expressed in liver.

Target Synonyms

MGST1; GST12; MGST; Microsomal glutathione S-transferase 1; Microsomal GST-1; Microsomal GST-I

Target Background

The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene.