Recombinant Human Migration and invasion enhancer 1 (MIEN1)

Uniprot Id

Q9BRT3

Target Species

Human

Target Name

MIEN1

Target Full Name

Migration and invasion enhancer 1

Target Function

Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process.

Target Subcellular Location

Cytoplasm, cytosol. Cell membrane; Lipid-anchor; Cytoplasmic side. Note=Concentrates at the leading edge of migrating cells. Localizes outside membrane raft regions.

Target Protein Families

SelWTH family

Target Tissue Specificity

Among normal tissues, present only in Leydig cells. Strongly up-regulated in breast cancers and in brain cancer distant metastasis (at protein level). Up-regulated in prostate cancer cells and in the higher grades of prostate adenocarcinoma (at protein le

Target Synonyms

C17orf37; C17orf37 homolog; C35; chromosome 17 open reading frame 37 ; HBV X transactivated gene 4 protein; HBV X-transactivated gene 4 protein; HBV XAg transactivated protein 4; HBV XAg-transactivated protein 4; MGC14832; Mien1; MIEN1_HUMAN; Migration and invasion enhancer 1; ORB3; Protein C17orf37; Protein C35; RDX12; Redox protein, 12-KD; XTP4

Target Background

Involved in negative regulation of apoptotic process; positive regulation of cell migration; and positive regulation of filopodium assembly. Located in several cellular components, including centriolar satellite; cytosol; and nucleoplasm. Is intrinsic component of the cytoplasmic side of the plasma membrane.