Recombinant Human Mini-chromosome maintenance complex-binding protein (MCMBP)

Uniprot Id

Q9BTE3

Target Species

Human

Target Name

MCMBP

Target Full Name

Mini-chromosome maintenance complex-binding protein

Target Function

Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion.

Target Subcellular Location

Nucleus. Note=Associates with chromatin. Highly associated with chromatin in G1/S and S phases, reduced binding to chromatin in G2, and further decreased binding in early M phase. It then reassociates with chromatin in late M phase. Dissociates from chromatin later than component of the MCM complex.

Target Protein Families

MCMBP family

Target Synonyms

MCMBP; C10orf119; Mini-chromosome maintenance complex-binding protein; MCM-BP; MCM-binding protein

Target Background

This gene encodes a protein which is a component of the hexameric minichromosome maintenance (MCM) complex which regulates initiation and elongation of DNA. Multiple transcript variants encoding different isoforms have been found for this gene.