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| Cat.No | ACP07108 | Target Name | Timm22 |
|---|---|---|---|
| Target Synonyms | TIMM22; TEX4; TIM22; Mitochondrial import inner membrane translocase subunit Tim22; Testis-expressed protein 4 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9Y584 |
|---|
Uniprot Id
Q9Y584
Target Species
Human
Target Name
TIMM22
Target Full Name
Mitochondrial import inner membrane translocase subunit Tim22
Target Function
Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.
Target Subcellular Location
Mitochondrion inner membrane; Multi-pass membrane protein.
Target Protein Families
Tim17/Tim22/Tim23 family
Target Synonyms
TIMM22; TEX4; TIM22; Mitochondrial import inner membrane translocase subunit Tim22; Testis-expressed protein 4
Target Background
Multipass transmembrane proteins are brought into mitochondria and inserted into the mitochondrial inner membrane by way of the TIM22 complex. This complex has six subunits and is a twin-pore translocase. The protein encoded by this gene is a subunit of TIM22 and represents the voltage-activated and signal-gated channel.
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