Recombinant Human Mitochondrial import inner membrane translocase subunit TIM44 (TIMM44), Truncated

Uniprot Id

O43615

Target Species

Human

Target Name

TIMM44

Target Full Name

Mitochondrial import inner membrane translocase subunit TIM44

Target Function

Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source.

Target Subcellular Location

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Mitochondrion matrix.

Target Protein Families

Tim44 family

Target Synonyms

TIMM44; MIMT44; TIM44; Mitochondrial import inner membrane translocase subunit TIM44

Target Background

This gene encodes a peripheral membrane protein associated with the mitochondrial inner membrane translocase, which functions in the import of proteins across the mitochondrial inner membrane and into the mitochondrial matrix. The encoded protein mediates binding of mitochondrial heat shock protein 70 to the translocase of inner mitochondrial membrane 23 (TIM23) complex. Expression of this gene is upregulated in kidney in a mouse model of diabetes. A mutation in this gene is associated with familial oncocytic thyroid carcinoma.