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| Cat.No | ACP01599 | Target Name | PMPCB |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 44-489aa | Mol Weight | 55.8 kDa |
| Protein Length | Full Length of Mature Protein | Purity | Greater than 85% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O75439 |
|---|
Uniprot Id
O75439
Target Species
Human
Target Name
PMPCB
Target Full Name
Mitochondrial-processing peptidase subunit beta
Target Function
Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins (Probable). Preferentially, cleaves after an arginine at position P2. Required for PINK1 turnover by coupling PINK1 mitochondrial import and cleavage, which results in subsequent PINK1 proteolysis.
Target Subcellular Location
Mitochondrion matrix.
Target Protein Families
Peptidase M16 family
Target Research Area
Cancer
Target Synonyms
Beta MPP; Beta-MPP; BetaMPP; Mitochondrial processing peptidase subunit beta; Mitochondrial-processing peptidase subunit beta; MPP11; MPPB; MPPB_HUMAN; MPPP52; P 52; P-52; P52; Peptidase mitichondrial processing beta; PMPCB
Target Background
This gene is a member of the peptidase M16 family and encodes a protein with a zinc-binding motif. This protein is located in the mitochondrial matrix and catalyzes the cleavage of the leader peptides of precursor proteins newly imported into the mitochondria, though it only functions as part of a heterodimeric complex.
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