Recombinant Human Mitogen-activated protein kinase 4 (MAPK4)

Uniprot Id

P31152

Target Species

Human

Target Name

MAPK4

Target Full Name

Mitogen-activated protein kinase 4

Target Function

Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle.

Target Subcellular Location

Cytoplasm. Nucleus.

Target Protein Families

Protein kinase superfamily, CMGC Ser/Thr protein kinase family, MAP kinase subfamily

Target Tissue Specificity

High expression in heart and brain.

Target Synonyms

ERK-4; ERK3; Erk3 related; ERK4; Extracellular signal regulated kinase 4; Extracellular signal-regulated kinase 4; MAP kinase 4; MAP kinase isoform p63; MAPK 4; MAPK4; Mitogen activated protein kinase 4; Mitogen-activated protein kinase 4; MK04_HUMAN; p63 MAPK; p63-MAPK; p63MAPK; PRKM4; Protein kinase; mitogen-activated; 4; Protein-tyrosine kinase ERK3-related; RMNK2

Target Background

Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth factor receptors activate mitogen-activated protein kinases which then translocate into the nucleus and phosphorylate nuclear targets. Alternative splicing results in multiple transcript variants.