Home Products Recombinant Human Mitogen-activated protein kinase kinase kinase 9 (MAP3K9), Truncated

Recombinant Human Mitogen-activated protein kinase kinase kinase 9 (MAP3K9), Truncated

ACP24616

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Specifications

Cat.No	ACP24616	Target Name	MAP3K9
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Protein Length	Partial	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	P80192

Background Information

Uniprot Id

P80192
Target Species

Human
Target Name

MAP3K9
Target Full Name

Mitogen-activated protein kinase kinase kinase 9
Target Function

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Plays also a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.
Target Involvement

May play a role in esophageal cancer susceptibility and/or development.
Target Protein Families

Protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily
Target Tissue Specificity

Expressed in epithelial tumor cell lines of colonic, breast and esophageal origin.
Target Synonyms

M3K9_HUMAN; Map3k9; MEKK9; Mitogen activated protein kinase kinase kinase 9; Mitogen-activated protein kinase kinase kinase 9; Mixed lineage kinase 1 (tyr and ser/thr specificity); Mixed lineage kinase 1; MLK1; PRKE1

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Recombinant Human Mitogen-activated protein kinase kinase kinase 9 (MAP3K9), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human Mitogen-activated protein kinase kinase kinase 9 (MAP3K9), Truncated Now

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