Recombinant Human Monocarboxylate transporter 4 (SLC16A3)

Uniprot Id

O15427

Target Species

Human

Target Name

SLC16A3

Target Full Name

Monocarboxylate transporter 4

Target Function

Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate.

Target Subcellular Location

Cell membrane; Multi-pass membrane protein.

Target Protein Families

Major facilitator superfamily, Monocarboxylate porter (TC 2.A.1.13) family

Target Tissue Specificity

Highly expressed in skeletal muscle.

Target Research Area

Cancer

Target Synonyms

MCT 4; MCT3; MCT4; Monocarboxylate transporter 3; Monocarboxylate transporter 4; MOT4_HUMAN; SLC16A3; Solute carrier family 16 member 3

Target Background

Lactic acid and pyruvate transport across plasma membranes is catalyzed by members of the proton-linked monocarboxylate transporter (MCT) family, which has been designated solute carrier family-16. Each MCT appears to have slightly different substrate and inhibitor specificities and transport kinetics, which are related to the metabolic requirements of the tissues in which it is found. The MCTs, which include MCT1 (SLC16A1; MIM 600682) and MCT2 (SLC16A7; MIM 603654), are characterized by 12 predicted transmembrane domains (Price et al., 1998 [PubMed 9425115]).