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Recombinant Human mRNA (2′-O-methyladenosine-N (6)-)-methyltransferase (PCIF1)

ACP10652

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Specifications

Cat.No	ACP10652	Target Name	PCIF1
Target Synonyms	bA465L10.1; C20orf67; Pcif1; PCIF1_HUMAN; PDX1 C terminal inhibiting factor 1; Phosphorylated CTD interacting factor 1; Phosphorylated CTD-interacting factor 1	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	1-704
Protein Length	Full length protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q9H4Z3

Background Information

Uniprot Id

Q9H4Z3
Target Species

Human
Target Name

PCIF1
Target Full Name

mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase
Target Function

Cap-specific adenosine methyltransferase that catalyzes formation of N(6),2'-O-dimethyladenosine cap (m6A(m)) by methylating the adenosine at the second transcribed position of capped mRNAs. Recruited to the early elongation complex of RNA polymerase II (RNAPII) via interaction with POLR2A and mediates formation of m6A(m) co-transcriptionally.
Target Subcellular Location

Nucleus.
Target Tissue Specificity

Ubiquitous.
Target Synonyms

bA465L10.1; C20orf67; Pcif1; PCIF1_HUMAN; PDX1 C terminal inhibiting factor 1; Phosphorylated CTD interacting factor 1; Phosphorylated CTD-interacting factor 1
Target Background

Enables RNA polymerase II C-terminal domain phosphoserine binding activity; S-adenosyl-L-methionine binding activity; and mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity. Involved in mRNA methylation; negative regulation of translation; and positive regulation of translation. Located in intercellular bridge; microtubule cytoskeleton; and nucleoplasm.

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Recombinant Human mRNA (2′-O-methyladenosine-N (6)-)-methyltransferase (PCIF1)

Specifications

Immunogen Information

Inquire Recombinant Human mRNA (2′-O-methyladenosine-N (6)-)-methyltransferase (PCIF1) Now

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