Recombinant Human mRNA-decapping enzyme 2 (DCP2)

Cat.No	ACP08832	Target Name	DCP2
Target Synonyms	DCP2; DCP2 decapping enzyme homolog (S. cerevisiae); DCP2, homolog of; DCP2_HUMAN; decapping enzyme 2, S. cerevisiae	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	1-385aa
Mol Weight	46.4kD	Protein Length	isoform 2
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP08832

Target Name

DCP2

Target Synonyms

DCP2; DCP2 decapping enzyme homolog (S. cerevisiae); DCP2, homolog of; DCP2_HUMAN; decapping enzyme 2, S. cerevisiae

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

1-385aa

Mol Weight

46.4kD

Protein Length

isoform 2

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q8IU60

Background Information

Uniprot Id

Q8IU60
Target Species

Human
Target Name

DCP2
Target Full Name

m7GpppN-mRNA hydrolase
Target Function

Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in replication-dependent histone mRNA degradation. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking an RNA moiety. The presence of a N(6)-methyladenosine methylation at the second transcribed position of mRNAs (N(6),2'-O-dimethyladenosine cap; m6A(m)) provides resistance to DCP2-mediated decapping. Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts.
Target Subcellular Location

Cytoplasm, P-body. Nucleus.
Target Protein Families

Nudix hydrolase family, DCP2 subfamily
Target Tissue Specificity

Expressed in brain and testis. Not detected in heart (at protein level).
Target Research Area

Transcription
Target Synonyms

DCP2; DCP2 decapping enzyme homolog (S. cerevisiae); DCP2, S. cerevisiae, homolog of; DCP2_HUMAN; decapping enzyme 2, S. cerevisiae, homolog of; decapping enzyme homolog (S. cerevisiae); FLJ33245; hDpc; m7GpppN-mRNA hydrolase; mRNA decapping enzyme 2; mRNA-decapping enzyme 2; Nucleoside diphosphate-linked moiety X motif 20; nudix (nucleoside diphosphate linked moiety X)-type motif 20; Nudix motif 20; NUDT20
Target Background

The protein encoded by this gene is a key component of an mRNA-decapping complex required for degradation of mRNAs, both in normal mRNA turnover, and in nonsense-mediated mRNA decay (NMD). It removes the 7-methyl guanine cap structure from mRNA, prior to its degradation from the 5' end. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Recombinant Human mRNA-decapping enzyme 2 (DCP2)

Specifications

Immunogen Information

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