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| Cat.No | ACP08079 | Target Name | MCOLN2 |
|---|---|---|---|
| Target Synonyms | MCOLN2; Mucolipin-2; Transient receptor potential channel mucolipin 2; TRPML2 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8IZK6 |
|---|
Uniprot Id
Q8IZK6
Target Species
Human
Target Name
MCOLN2
Target Full Name
Mucolipin-2
Target Function
Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca(2+)-permeable cation channel with inwardly rectifying activity. May activate ARF6 and be involved in the trafficking of GPI-anchored cargo proteins to the cell surface via the ARF6-regulated recycling pathway. May play a role in immune processes. In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells. In the innate immune response, may play a role in the regulation of chemokine secretion and macrophage migration. Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events
Target Subcellular Location
Cell membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein.
Target Protein Families
Transient receptor (TC 1.A.4) family, Polycystin subfamily, MCOLN2 sub-subfamily
Target Synonyms
MCOLN2; Mucolipin-2; Transient receptor potential channel mucolipin 2; TRPML2
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