Recombinant Human Multiple epidermal growth factor-like domains protein 10 (MEGF10), Truncated

Cat.No	ACP14678	Target Name	MEGF10
Target Synonyms	MEGF10; KIAA1780Multiple epidermal growth factor-like domains protein 10; Multiple EGF-like domains protein 10	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Protein Length	Partial
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP14678

Target Name

MEGF10

Target Synonyms

MEGF10; KIAA1780Multiple epidermal growth factor-like domains protein 10; Multiple EGF-like domains protein 10

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Protein Length

Partial

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q96KG7

Background Information

Uniprot Id

Q96KG7
Target Species

Human
Target Name

MEGF10
Target Full Name

Multiple epidermal growth factor-like domains protein 10
Target Function

Membrane receptor involved in phagocytosis by macrophages and astrocytes of apoptotic cells. Receptor for C1q, an eat-me signal, that binds phosphatidylserine expressed on the surface of apoptotic cells. Cooperates with ABCA1 within the process of engulfment. Promotes the formation of large intracellular vacuoles and may be responsible for the uptake of amyloid-beta peptides. Necessary for astrocyte-dependent apoptotic neuron clearance in the developing cerebellum. Plays role in muscle cell proliferation, adhesion and motility. Is also an essential factor in the regulation of myogenesis. Controls the balance between skeletal muscle satellite cells proliferation and differentiation through regulation of the notch signaling pathway. May also function in the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements.
Target Involvement

Myopathy, early-onset, areflexia, respiratory distress, and dysphagia (EMARDD)
Target Subcellular Location

Cell membrane; Single-pass type I membrane protein. Cell projection, phagocytic cup.
Target Protein Families

MEGF family
Target Synonyms

MEGF10; KIAA1780Multiple epidermal growth factor-like domains protein 10; Multiple EGF-like domains protein 10
Target Background

This gene encodes a member of the multiple epidermal growth factor-like domains protein family. The encoded protein plays a role in cell adhesion, motility and proliferation, and is a critical mediator of apoptotic cell phagocytosis as well as amyloid-beta peptide uptake in the brain. Expression of this gene may be associated with schizophrenia, and mutations in this gene are a cause of early-onset myopathy, areflexia, respiratory distress, and dysphagia (EMARDD) as well as congenital myopathy with minicores. Alternatively spliced transcript variants have been observed for this gene.

Recombinant Human Multiple epidermal growth factor-like domains protein 10 (MEGF10), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human Multiple epidermal growth factor-like domains protein 10 (MEGF10), Truncated Now

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