Recombinant Human Multiple inositol polyphosphate phosphatase 1 (MINPP1)

Uniprot Id

Q9UNW1

Target Species

Human

Target Name

MINPP1

Target Full Name

Multiple inositol polyphosphate phosphatase 1

Target Function

Acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3-phosphoglycerate. May play a role in bone development (endochondral ossification). May play a role in the transition of chondrocytes from proliferation to hypertrophy.

Target Involvement

Thyroid cancer, non-medullary, 2 (NMTC2)

Target Subcellular Location

Endoplasmic reticulum lumen.

Target Protein Families

Histidine acid phosphatase family, MINPP1 subfamily

Target Tissue Specificity

Widely expressed with highest levels in kidney, liver and placenta.

Target Research Area

Signal Transduction

Target Synonyms

3; 4; 5)-tetrakisphosphate 3-phosphatase; 5)P(4) 3-phosphatase; DKFZp564L2016; HIPER1; Inositol (1; inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase; Ins(1; ins(1,3,4,5)P(4) 3-phosphatase; MINP1_HUMAN; Minpp1; MINPP2; MIPP; Multiple inositol polyphosphate histidine phosphatase, 1; Multiple inositol polyphosphate phosphatase 1; multiple inositol polyphosphate phosphatase 2

Target Background

This gene encodes multiple inositol polyphosphate phosphatase; an enzyme that removes 3-phosphate from inositol phosphate substrates. It is the only enzyme known to hydrolzye inositol pentakisphosphate and inositol hexakisphosphate. This enzyme also converts 2, 3 bisphosphoglycerate (2, 3-BPG) to 2-phosphoglycerate; an activity formerly thought to be exclusive to 2, 3-BPG synthase/2-phosphatase (BPGM) in the Rapoport-Luebering shunt of the glycolytic pathway.