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Recombinant Human Muscular LMNA-interacting protein (MLIP)

ACP16864

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Specifications

Cat.No	ACP16864	Target Name	MLIP
Target Synonyms	C6orf142; MLIP; MLIP_HUMAN; Muscle enriched A type lamin interacting protein; Muscular LMNA-interacting protein; Muscular-enriched A-type laminin-interacting protein; RP11-642N5.1	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	1-458
Protein Length	Full length protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q5VWP3

Background Information

Uniprot Id

Q5VWP3
Target Species

Human
Target Name

MLIP
Target Full Name

Muscular LMNA-interacting protein
Target Function

Required for precocious cardiac adaptation to stress through integrated regulation of the AKT/mTOR pathways and FOXO1. Regulates cardiac homeostasis and plays an important role in protection against cardiac hypertrophy. Acts as a transcriptional cofactor, represses transactivator activity of ISL1 and MYOCD.
Target Involvement

Expression is reduced in patients with dilated cardiomyocytes. In murine cardiomyopathy models, deletion of the encoding gene accelerates progress from hypertrophy to heart failure.
Target Subcellular Location

Nucleus. Nucleus envelope. Nucleus, PML body. Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side.
Target Tissue Specificity

Primarily expressed in heart and skeletal muscle. Also detected in liver.
Target Synonyms

C6orf142; MLIP; MLIP_HUMAN; Muscle enriched A type lamin interacting protein; Muscular LMNA-interacting protein; Muscular-enriched A-type laminin-interacting protein; RP11-642N5.1

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Recombinant Human Muscular LMNA-interacting protein (MLIP)

Specifications

Immunogen Information

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