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| Cat.No | ACP10097 | Target Name | MKLN1 |
|---|---|---|---|
| Target Synonyms | intracellular mediator containing kelch motifs ; Muskelin; TWA2; Two-hybrid-associated protein with Ranbpm 2, MKLN 1; Mkln1; MKLN1_HUMAN; muskelin 1 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 2-735 |
| Protein Length | Full Length of Mature Protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9UL63 |
|---|
Uniprot Id
Q9UL63
Target Species
Human
Target Name
MKLN1
Target Full Name
Muskelin
Target Function
Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Required for internalization of the GABA receptor GABRA1 from the cell membrane via endosomes and subsequent GABRA1 degradation. Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1.
Target Subcellular Location
Cytoplasm. Cytoplasm, cytosol. Nucleus, nucleoplasm. Cell projection, ruffle. Cytoplasm, cell cortex. Cell junction, synapse. Cell junction, synapse, postsynapse.
Target Synonyms
MKLN 1; Mkln1; MKLN1_HUMAN; muskelin 1, intracellular mediator containing kelch motifs ; Muskelin; TWA2; Two-hybrid-associated protein with Ranbpm 2
Target Background
Muskelin is an intracellular protein that acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component thrombospondin I (MIM 188060) (Adams et al., 1998 [PubMed 9724633]).
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