Recombinant Human MutS protein homolog 5 (MSH5), Truncated

Uniprot Id

O43196

Target Species

Human

Target Name

MSH5

Target Full Name

MutS protein homolog 5

Target Function

Involved in DNA mismatch repair and meiotic recombination processes. Facilitates crossovers between homologs during meiosis.

Target Involvement

Premature ovarian failure 13 (POF13)

Target Protein Families

DNA mismatch repair MutS family

Target Tissue Specificity

Widely expressed, with high levels in testis and ovary, including granulosa cells. Also expressed in fetal ovary and adrenal gland.

Target Synonyms

DKFZp434C1615; G7; hMSH5; MGC2939; MSH 5; MSH5; MSH5_HUMAN; mutS (E. coli) homolog 5 ; mutS homolog 5 ; mutS homolog 5 (E. coli); MutS protein homolog 5; MutSH5; NG23; OTTHUMP00000029187; OTTHUMP00000029188

Target Background

This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair and meiotic recombination. This protein is similar to a Saccharomyces cerevisiae protein that participates in segregation fidelity and crossing-over events during meiosis. This protein plays a role in promoting ionizing radiation-induced apoptosis. This protein forms hetero-oligomers with another member of this family, mutS homolog 4. Polymorphisms in this gene have been linked to various human diseases, including IgA deficiency, common variable immunodeficiency, and premature ovarian failure. Alternative splicing results multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 6 open reading frame 26 (C6orf26) gene.