Recombinant Human Myocyte-specific enhancer factor 2A (MEF2A)

Cat.No	ACP24498	Target Name	MEF2A
Target Synonyms	ADCAD1; MADS box transcription enhancer factor 2	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	1-507
Protein Length	Full length protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP24498

Target Name

MEF2A

Target Synonyms

ADCAD1; MADS box transcription enhancer factor 2

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

1-507

Protein Length

Full length protein

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q02078

Background Information

Uniprot Id

Q02078
Target Species

Human
Target Name

MEF2A
Target Full Name

Myocyte-specific enhancer factor 2A
Target Function

Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter.
Target Involvement

Coronary artery disease, autosomal dominant, 1 (ADCAD1)
Target Subcellular Location

Nucleus.
Target Protein Families

MEF2 family
Target Tissue Specificity

Isoform MEF2 and isoform MEFA are expressed only in skeletal and cardiac muscle and in the brain. Isoform RSRFC4 and isoform RSRFC9 are expressed in all tissues examined.
Target Synonyms

ADCAD1; MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A) ; MEF2; MEF2A; MEF2A_HUMAN; Myocyte enhancer factor 2A; Myocyte-specific enhancer factor 2A; RSRFC4; RSRFC9; Serum response factor like protein 1 ; Serum response factor-like protein 1
Target Background

The protein encoded by this gene is a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. The encoded protein can act as a homodimer or as a heterodimer and is involved in several cellular processes, including muscle development, neuronal differentiation, cell growth control, and apoptosis. Defects in this gene could be a cause of autosomal dominant coronary artery disease 1 with myocardial infarction (ADCAD1). Several transcript variants encoding different isoforms have been found for this gene.

Recombinant Human Myocyte-specific enhancer factor 2A (MEF2A)

Specifications

Immunogen Information

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