Home Products Recombinant Human Myotubularin-related protein 13 (SBF2), Truncated

Recombinant Human Myotubularin-related protein 13 (SBF2), Truncated

ACP15488

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Specifications

Cat.No	ACP15488	Target Name	SBF2
Target Synonyms	SBF2; CMT4B2; KIAA1766; MTMR13; Myotubularin-related protein 13; Inactive phosphatidylinositol 3-phosphatase 13; SET-binding factor 2	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Protein Length	Partial
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q86WG5

Background Information

Uniprot Id

Q86WG5
Target Species

Human
Target Name

SBF2
Target Full Name

Myotubularin-related protein 13
Target Function

Guanine nucleotide exchange factor (GEF) which activates RAB21 and possibly RAB28. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. In response to starvation-induced autophagy, activates RAB21 which in turn binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion. Acts as an adapter for the phosphatase MTMR2. Increases MTMR2 catalytic activity towards phosphatidylinositol 3,5-bisphosphate and to a lesser extent towards phosphatidylinositol 3-phosphate.
Target Involvement

Charcot-Marie-Tooth disease 4B2 (CMT4B2)
Target Subcellular Location

Cytoplasm. Cytoplasm, perinuclear region. Membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Cell projection, axon.
Target Protein Families

Protein-tyrosine phosphatase family, Non-receptor class myotubularin subfamily
Target Tissue Specificity

Widely expressed. Expressed in spinal cord.
Target Synonyms

SBF2; CMT4B2; KIAA1766; MTMR13; Myotubularin-related protein 13; Inactive phosphatidylinositol 3-phosphatase 13; SET-binding factor 2

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Recombinant Human Myotubularin-related protein 13 (SBF2), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human Myotubularin-related protein 13 (SBF2), Truncated Now

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