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Recombinant Human N-lysine methyltransferase SMYD2 (SMYD2)

ACP10584

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High Purity LevelsPrecision and ReliabilityCustomization Options

Specifications

Cat.No	ACP10584	Target Name	SMYD2
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Expression Range	1-433	Protein Length	Full length protein
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q9NRG4

Background Information

Uniprot Id

Q9NRG4
Target Species

Human
Target Name

SMYD2
Target Full Name

N-lysine methyltransferase SMYD2
Target Function

Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'.
Target Subcellular Location

Cytoplasm, cytosol. Nucleus.
Target Protein Families

Class V-like SAM-binding methyltransferase superfamily
Target Synonyms

Histone methyltransferase SMYD2; HSKM B; HSKM-B; HSKMB; KMT3C; Lysine N-methyltransferase 3C; MGC119305; N lysine methyltransferase SMYD2; N-lysine methyltransferase SMYD2; SET and MYND domain containing 2; SET and MYND domain containing protein 2; SET and MYND domain-containing protein 2; Smyd2; SMYD2_HUMAN; Zinc finger MYND domain containing 14; ZMYND14
Target Background

SET domain-containing proteins, such as SMYD2, catalyze lysine methylation (Brown et al., 2006 [PubMed 16805913]).

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Recombinant Human N-lysine methyltransferase SMYD2 (SMYD2)

Specifications

Immunogen Information

Inquire Recombinant Human N-lysine methyltransferase SMYD2 (SMYD2) Now

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