Recombinant Human NAD (P)H-hydrate epimerase (NAXE)

Uniprot Id

Q8NCW5

Target Species

Human

Target Name

NAXE

Target Full Name

NAD(P)H-hydrate epimerase

Target Function

Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. Accelerates cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis.

Target Involvement

Encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy (PEBEL)

Target Subcellular Location

Mitochondrion. Secreted.

Target Protein Families

NnrE/AIBP family

Target Tissue Specificity

Ubiquitously expressed, with highest levels in kidney, heart and liver. Present in cerebrospinal fluid and urine but not in serum from healthy patients. Present in serum of sepsis patients (at protein level).

Target Synonyms

NAXE; AIBP; APOA1BP; YJEFN1; NAD(P)H-hydrate epimerase; EC 5.1.99.6; Apolipoprotein A-I-binding protein; AI-BP; NAD(P)HX epimerase; YjeF N-terminal domain-containing protein 1; YjeF_N1

Target Background

The product of this gene interacts with apolipoprotein A-I (apoA-I), the major apolipoprotein of high-density lipoproteins (HDLs). It is secreted into some bodily fluids, and its synthesis and secretion are stimulated in vitro by incubating cells with apoA-I. The human genome contains related pseudogenes.