Recombinant Human NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (NDUFA2)

Uniprot Id

O43678

Target Species

Human

Target Name

NDUFA2

Target Full Name

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2

Target Function

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Target Subcellular Location

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Target Protein Families

Complex I NDUFA2 subunit family

Target Research Area

Transport

Target Synonyms

B8; CI B8; CI-B8; Complex I B8; Complex I-B8; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 2 8kDa; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2; NADH ubiquinone oxidoreductase B8 subunit; NADH-ubiquinone oxidoreductase B8 subunit; NDUA2_HUMAN; NDUFA 2; Ndufa2

Target Background

The encoded protein is a subunit of the hydrophobic protein fraction of the NADH:ubiquinone oxidoreductase (complex 1), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane, and may be involved in regulating complex I activity or its assembly via assistance in redox processes. Mutations in this gene are associated with Leigh syndrome, an early-onset progressive neurodegenerative disorder. Alternative splicing results in multiple transcript variants.