Recombinant Human NADPH oxidase activator 1 (NOXA1)

Uniprot Id

Q86UR1

Target Species

Human

Target Name

NOXA1

Target Full Name

NADPH oxidase activator 1

Target Function

Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3.

Target Subcellular Location

Cytoplasm. Cell membrane. Note=Translocation to membranes depends on NOXO1 or NCF1 and maybe RAC1.

Target Protein Families

NCF2/NOXA1 family

Target Tissue Specificity

Widely expressed. Detected in pancreas, liver, kidney, spleen, prostate, small intestine and colon.

Target Synonyms

Antigen NY CO 31; Antigen NY-CO-31; FLJ25475; Inhibitory NADPH oxidase activator 1; MGC131800; NADPH oxidase activator 1; NCF2 like protein; NCF2-like protein; NOX activator 1; NOXA 1; Noxa1; NOXA1_HUMAN; NY CO 31; p51 nox; p51-nox; p51NOX; P67phox like factor; P67phox-like factor; SDCCAG31; Serologically defined colon cancer antigen 31

Target Background

This gene encodes a protein which activates NADPH oxidases, enzymes which catalyze a reaction generating reactive oxygen species. The encoded protein contains four N-terminal tetratricopeptide domains and a C-terminal Src homology 3 domain. Interaction between the encoded protein and proteins in the oxidase regulatory complex occur via the tetratricopeptide domains. Multiple transcript variants encoding different isoforms have been found for this gene.