Recombinant Human Neogenin (NEO1), Truncated

Uniprot Id

Q92859

Target Species

Human

Target Name

NEO1

Target Full Name

Neogenin

Target Function

Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response.

Target Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Target Protein Families

Immunoglobulin superfamily, DCC family

Target Tissue Specificity

Widely expressed and also in cancer cell lines.

Target Synonyms

Immunoglobulin superfamily DCC subclass member 2; NEO1; NEO1_HUMAN; Neogenin; Ngn (gene name)

Target Background

This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may be involved in cell growth and differentiation and in cell-cell adhesion. Defects in this gene are associated with cell proliferation in certain cancers. Alternate splicing results in multiple transcript variants.